Schistosoma mansoni: reinfections and concomitant immunity in mice: importance of perfusion time after challenge infection for evaluation of immunoprotection
نویسندگان
چکیده
منابع مشابه
Concomitant immunity to Schistosoma mansoni in mice.
OBJECTIVE The aim of the present study was to confirm observations on the concomitant immunity to Schistosoma mansoni in mice and assess its effects on the resistance of mice to a challenge infection. METHODS Cercariae from infected Biomphalaria glabrata were used to infect mice. Twenty mice were infected with a single dose of S. mansoni cercariae. The animals were randomly divided into two g...
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Fourteen-day-old schistosomula obtained from mice previously infected were surgically transferred to the portal vein of receptor mice. Another group of mice was infected with cercariae by transcutaneous route. After 90 days, those groups were challenged with 100 cercariae, transcutaneously, as well as a control group. Two weeks later the animals were perfused and mature and immature worms count...
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Schistosoma mansoni, an intravascular parasite, lives in a hostile environment in close contact with host humoral and cellular cytotoxic factors. To establish itself in the host, the parasite has evolved a number of immune evasion mechanisms, such as antioxidant enzymes. Our laboratory has demonstrated that the expression of antioxidant enzymes is developmentally regulated, with the highest lev...
متن کاملTherapeutic effect of subcurative dose praziquantel on Schistosoma mansoni infected mice and resistance to challenge infection after treatment.
The therapeutic effect of a subcurative dosage of praziquantel (PZQ) on Schistosoma mansoni infected mice and resistance to challenged worm infection after treatment were assessed and compared with conventional treatment using a curative dosage of PZQ. S. mansoni infected mice were treated with PZQ at a curative dosage (600 mg kg(-1)) or a subcurative dosage (300 mg kg(-1)) at 9 weeks after inf...
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ژورنال
عنوان ژورنال: Memórias do Instituto Oswaldo Cruz
سال: 1995
ISSN: 0074-0276
DOI: 10.1590/s0074-02761995000400014